The application process for potential provincial nominees varies from province to province and you should check the specifics of the province you are interested in living and working in before applying.
Having been nominated by your province, and thereby having satisfied their requirements, you then need to apply for permanent residency through the usual Canadian immigration channels.
This involves sending the Visa forms and including the form specific to nominees nominated via the provincial nomination programme. Details can be found on the official Canadian government website or from your nearest Canadian embassy, commission or consulate.
The process also varies slightly depending on the nomination stream you have entered into – be it business, skilled worker or as a relative or dependent of another. There are some common factors however. It is worth remembering that the immigration authority has the final say on the success or failure of your application. Completed application forms should be submitted to the Canadian Visa Office responsible for the specific country you currently reside in or the country of your nationality.